Prolactinoma - Are there any drawbacks to therapy and how long will I need to take the drug?

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The major disadvantage of bromocriptine and cabergoline is that stopping either drug leads to recurrence of hyperprolactinemia and tumor regrowth. It is not possible to accurately predict which patients may safely stop the drug. If you have a microadenoma , your doctor will likely recommend treatment for at least 2 years before considering tapering or stopping the drug.

Since tumor regrowth often occurs, close follow-up and repeat measurements of prolactin will be necessary after stopping medical therapy. Successful long-term discontinuation of the drug may be possible in a few patients, but patients with macroadenomas will likely need medical therapy indefinitely.